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Comparative Phylogenomics of <i>Clostridium difficile</i> Reveals Clade Specificity and Microevolution of Hypervirulent Strains

1 Oct 2006

Abstract excerpt

Clostridium difficile is the most frequent cause of nosocomial diarrhea worldwide, and recent reports suggested the emergence of a hypervirulent strain in North America and Europe. In this study, we applied comparative phylogenomics (whole-genome comparisons using DNA microarrays combined with Bayesian phylogenies) to model the phylogeny of C. difficile, including 75 diverse isolates comprising hypervirulent,...

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PMID: 17015669
DOI: 10.1128/jb.00664-06

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