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Genetically related micafungin-resistant Candida parapsilosis blood isolates harbouring novel mutation R658G in hotspot 1 of Fks1p: a new challenge?

The Journal of antimicrobial chemotherapy - 19 Jan 2021

Arastehfar Amir, Daneshnia Farnaz, Hilmioglu-Polat Süleyha, Ilkit Macit, Yasar Melike, Polat Furkan, Metin Dilek Yeşim, Dokumcu Ülküm Zafer, Pan Weihua, Hagen Ferry, Boekhout Teun, Perlin David S, Lass-Flörl Cornelia

Abstract excerpt

BACKGROUND: Echinocandin resistance rarely occurs in clinical Candida parapsilosis isolates and the underlying mechanism is unknown. OBJECTIVES: To determine the prevalence of echinocandin resistance and the underlying mechanism for a large collection of C. parapsilosis blood isolates and to determine whether the echinocandin-resistant isolates were clonally related. METHODS: C. parapsilosis blood isolates...

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Antifungal Agents
Antifungal resistance and susceptibility
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Drug Resistance, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

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PMID: 33175162
DOI: 10.1093/jac/dkaa419

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