Article
Inflammatory stress in primary venous and aortic endothelial cells of type 1 diabetic mice.
Diabetes & vascular disease research - 1 Oct 2009
Bucciarelli Loredana G, Pollreisz Andreas, Kebschull Moritz, Ganda Anjali, Kalea Anastasia Z, Hudson Barry I, Zou Yu Shan, Lalla Evanthia, Ramasamy Ravichandran, Colombo Paolo C, Schmidt Ann Marie, Yan Shi Fang
Abstract excerpt
OBJECTIVE: The progression of diabetes is associated with profound endothelial dysfunction. We tested the hypothesis that cellular stress would be detectable in ECs retrieved from arterial and venous vessels of diabetic mice. METHOD: We describe a method for direct isolation of well-characterised aortic and venous ECs from mice in which cells are not subjected to propagation in culture. RESULTS: Gene expression...
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