Solution structure of an oncogenic DNA duplex containing a G.A mismatch.

doi:10.1021/bi00236a018

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Article

Solution structure of an oncogenic DNA duplex containing a G.A mismatch.

Biochemistry - 4 Jun 1991

Carbonnaux C, van der Marel G A, van Boom J H, Guschlbauer W, Fazakerley G V

Abstract excerpt

The DNA duplex 5'-d(GCCACAAGCTC).d(GAGCTGGTGGC), which contains a central G.A mismatch has been studied by one and two-dimensional NMR techniques. The duplex corresponds to the sequence 29-39 of the K-ras gene. The mismatch position is that of the first base of the Gly12 codon, a hot spot for mut...

Topics

Base Composition
Base Sequence
DNA
DNA Repair
Genes, ras
Hydrogen Bonding
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Solutions

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