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Article

Solution structures of human transforming growth factor alpha derived from 1H NMR data.

Biochemistry - 28 Aug 1990

Kline T P, Brown F K, Brown S C, Jeffs P W, Kopple K D, Mueller L

Abstract excerpt

The 600-MHz 1H NMR spectrum of the des-Val-Val mutant of human transforming growth factor alpha (TGF-alpha) was reassigned at pH = 6.3. The conformation space of des-Val-Val TGF-alpha was explored by distance geometry embedding followed by restrained molecular dynamics refinement using NOE distance constraints and some torsion angle constraints derived from J-couplings. Over 80 long-range NOE constraints were...

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PMID: 2261437
DOI: 10.1021/bi00486a005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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