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Article

mTOR Signaling from Cellular Senescence to Organismal Aging

1 Jan 2014

Abstract excerpt

The TOR (target of rapamycin) pathway has been convincingly shown to promote aging in various model organisms. In mice, inhibiting mTOR (mammalian TOR) by rapamycin treatment later in life can significantly extend lifespan and mitigate multiple age-related diseases. However, the underlying mechanisms are poorly understood. Cellular senescence is strongly correlated to organismal aging therefore providing an...

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Share to Circadian rhythm and melatonin
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Identifiers

PMID: 25110610
DOI: 10.14336/ad.2014.0500263

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