Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of JAK2-V617F by components of heterodimeric cytokine receptors.

The Journal of biological chemistry - 28 May 2010

Pradhan Anuradha, Lambert Que T, Griner Lori N, Reuther Gary W

Abstract excerpt

The JAK2-V617F mutation is an important etiologic factor for the development of myeloproliferative neoplasms. The mechanism by which this mutated tyrosine kinase initiates deregulated signals in cells is not completely understood. It is believed that JAK2-V617F requires interactions with homodimeric cytokine receptors to elicit its transforming signal. In this study, we demonstrate that components of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Cytokines
Share to Dimerization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Activation

Share to Janus Kinase 2

Share to Phosphorylation

Share to Protein Structure, Secondary

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 20363735
DOI: 10.1074/jbc.M109.071191
PMCID: PMC2878064

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of JAK2-V617F by components of heterodimeric cytokine receptors.PMID 20363735Read ↗

JAK2 activation in myeloproliferative neoplasms: a potential role for heterodimeric receptors.Semantic proximity Read ↗

Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptorSemantic proximity Read ↗

Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation.Semantic proximity Read ↗

Signaling mechanisms of cytokine receptors and their perturbances in disease.Semantic proximity Read ↗

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity.Semantic proximity Read ↗

Signaling from the IL-2 receptor to the nucleus.Semantic proximity Read ↗

The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis.Semantic proximity Read ↗

Specificity of signaling by hematopoietic cytokine receptors: instructive versus permissive effects.Semantic proximity Read ↗

Distinct domains of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit mediate activation of Jak/Stat signaling and differentiation.Semantic proximity Read ↗

Identification of amino acids in transmembrane domains of mutated cytokine receptor-like factor 2 and interleukin-7 receptor α required for constitutive signal transduction.Semantic proximity Read ↗

Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.Semantic proximity Read ↗

Cytokine receptors and signal transduction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.