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Article

Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

7 Dec 2010

Abstract excerpt

Aberrant activation of Hedgehog (HH) signaling is implicated in many human cancers. Classical HH signaling is characterized by Smoothened (Smo)-dependent activation of Gli1 and Gli2, which transcriptionally regulate target genes. A small molecule inhibitor of Gli1 and Gli2, GANT61, was used to block HH signaling in human colon carcinoma cell lines that express HH signaling components. GANT61 administration...

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PMID: 21135115
DOI: 10.1158/0008-5472.can-10-2315

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