Article
HOW is required for stem cell maintenance in the Drosophila testis and for the onset of transit-amplifying divisions.
Cell stem cell - 2 Apr 2010
Monk Adrian C, Siddall Nicole A, Volk Talila, Fraser Barbara, Quinn Leonie M, McLaughlin Eileen A, Hime Gary R
Abstract excerpt
The mechanisms by which germline stem cells (GSCs) in the Drosophila testis undergo asymmetric division to regenerate a stem cell as well as a daughter (gonialblast) that will only undergo a further four mitotic divisions prior to entering premeiotic S phase and differentiating into a cyst of spermatocytes are not fully resolved. Here we demonstrate that the HOW RNA-binding protein is required for maintenance of...
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