Article
Arsenic binding and transfer by the ArsD As(III) metallochaperone.
Biochemistry - 4 May 2010
Yang Jianbo, Rawat Swati, Stemmler Timothy L, Rosen Barry P
Abstract excerpt
ArsD is a metallochaperone that delivers trivalent metalloids [As(III) or Sb(III)] to the ArsA ATPase, the catalytic subunit of the ArsAB pump encoded by the arsRDABC operon of Escherichia coli plasmid R773. Interaction with ArsD increases the affinity of ArsA for As(III), conferring resistance to environmental concentrations of arsenic. Previous genetic analysis suggested that ArsD residues Cys12, Cys13, and...
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