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Article

Design and Prototyping of Genetically Encoded Arsenic Biosensors Based on Transcriptional Regulator AfArsR.

Biomolecules - 26 Aug 2021

Khan Salma Saeed, Shen Yi, Fatmi Muhammad Qaiser, Campbell Robert E, Bokhari Habib

Abstract excerpt

Genetically encoded biosensors based on engineered fluorescent proteins (FPs) are essential tools for monitoring the dynamics of specific ions and molecules in biological systems. Arsenic ion in the +3 oxidation state (As3+) is highly toxic to cells due to its ability to bind to protein thiol groups, leading to inhibition of protein function, disruption of protein-protein interactions, and eventually to cell...

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Identifiers

PMID: 34572489
DOI: 10.3390/biom11091276
PMCID: PMC8470949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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