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Article

Cys-113 and Cys-422 form a high affinity metalloid binding site in the ArsA ATPase.

The Journal of biological chemistry - 14 Apr 2006

Ruan Xiang, Bhattacharjee Hiranmoy, Rosen Barry P

Abstract excerpt

The arsRDABC operon of Escherichia coli plasmid R773 encodes the ArsAB extrusion pump for the trivalent metalloids As(III) and Sb(III). ArsA, the catalytic subunit has two homologous halves, A1 and A2. Each half has a consensus signal transduction domain that physically connects the nucleotide-binding domain to the metalloid-binding domain. The relation between metalloid binding by ArsA and transport through ArsB...

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PMID: 16467301
DOI: 10.1074/jbc.M600125200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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