Article
Role of vicinal cysteine pairs in metalloid sensing by the ArsD As(III)-responsive repressor.
Molecular microbiology - 1 Aug 2001
Li S, Chen Y, Rosen B P
Abstract excerpt
ArsD is a 120-residue repressor that regulates expression of the arsRDABC arsenical resistance operon of plasmid R773 in Escherichia coli. ArsD is released from arsRDABC promoter DNA by binding of the compounds with the metalloids As(III) or Sb(III). ArsD has three vicinal cysteine pairs, Cys-12 and Cys-13, Cys-112 and Cys-113 and Cys-119 and Cys-120. In this study, the role of these three cysteine pairs was...
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