Article
Oxidative stress and ATPase6 mutation is associated with primary ovarian insufficiency.
Archives of gynecology and obstetrics - 1 Sept 2010
Venkatesh S, Kumar M, Sharma A, Kriplani A, Ammini A C, Talwar P, Agarwal A, Dada Rima
Abstract excerpt
PURPOSE: Primary ovarian insufficiency (POI) is a heterogeneous, multifactorial disorder. Though genetic anomalies, infections, autoimmune disorder and hormonal imbalance are few of the causes of POI, in the majority of patients (50-60%) no etiology has been identified. Mitochondrial bioenergetics and biogenesis play an important role in oocyte and embryo development, whereas mtDNA integrity and content are...
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