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Article

Oxidative stress and sperm mitochondrial DNA mutation in idiopathic oligoasthenozoospermic men.

Indian journal of biochemistry & biophysics - 1 Apr 2009

Kumar R, Venkatesh S, Kumar M, Tanwar M, Shasmsi M B, Kumar R, Gupta N P, Sharma R K, Talwar P, Dada Rima

Abstract excerpt

Physiological function of reactive oxygen species (ROS) has been known since a long, but recently toxic effects of ROS on spermatozoa have gained much importance in male infertility. Mitochondrial DNA (mtDNA) is believed to be both source and target of ROS. mtDNA unlike nuclear DNA is not compactly packed and hence more susceptible to oxidative stress (OS) than nuclear DNA. In the present study, the role of OS in...

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PMID: 19517995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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