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Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines

28 Jan 2023

Abstract excerpt

Nonreplicating adenovirus-based vectors have been successfully implemented as prophylactic vaccines against infectious viral diseases and induce protective cellular and humoral responses. Differences in the mechanisms of cellular entry or endosomal escape of these vectors contribute to differences in innate immune sensing between adenovirus species. Innate immune responses to adenovirus-based vaccines, such as...

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PMID: 36716578
DOI: 10.1016/j.coi.2023.102282

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