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Article

Mechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells.

PLoS pathogens - 1 Feb 2007

Cheng Cheng, Gall Jason G D, Kong Wing-pui, Sheets Rebecca L, Gomez Phillip L, King C Richter, Nabel Gary J

Abstract excerpt

Recombinant adenoviral (rAd) vectors elicit potent cellular and humoral immune responses and show promise as vaccines for HIV-1, Ebola virus, tuberculosis, malaria, and other infections. These vectors are now widely used and have been generally well tolerated in vaccine and gene therapy clinical trials, with many thousands of people exposed. At the same time, dose-limiting adverse responses have been observed,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17319743
DOI: 10.1371/journal.ppat.0030025
PMCID: PMC1803013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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