Article
Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation.
Circulation research - 30 Mar 2001
Niwa K, Haensel C, Ross M E, Iadecola C
Abstract excerpt
Cyclooxygenase (COX) is a prostanoid-synthesizing enzyme present in 2 isoforms: COX-1 and COX-2. Although it has long been hypothesized that prostanoids participate in cerebrovascular regulation, the lack of adequate pharmacological tools has led to conflicting results and has not permitted investigators to define the relative contribution of COX-1 and COX-2. We used the COX-1 inhibitor SC-560 and COX-1-null...
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