Article
Selection and characterization of Anticalins targeting human prostate-specific membrane antigen (PSMA).
Protein engineering, design & selection : PEDS - 1 Mar 2016
Barinka Cyril, Ptacek Jakub, Richter Antonia, Novakova Zora, Morath Volker, Skerra Arne
Abstract excerpt
Although prostate carcinoma (PCa) is by far the most commonly diagnosed neoplasia in men, corresponding diagnostic and therapeutic modalities have limited efficacy at present. Anticalins comprise a novel class of binding proteins based on a non-immunoglobulin scaffold that can be engineered to specifically address molecular targets of interest. Here we report the selection and characterization of Anticalins that...
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