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Article

Sodium channels and neurological disease: insights from Scn8a mutations in the mouse.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry - 1 Apr 2001

Meisler M H, Kearney J, Escayg A, MacDonald B T, Sprunger L K

Abstract excerpt

The human genome contains 10 voltage-gated sodium channel genes, 7 of which are expressed in neurons of the CNS and PNS. The availability of human genome sequences and high-throughput mutation screening methods make it likely that many human disease mutations will be identified in these genes in the near future. Mutations of Scn8a in the mouse demonstrate the broad spectrum of neurological disease that can result...

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Identifiers

PMID: 11496924
DOI: 10.1177/107385840100700208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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