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Article

Cerebellum-related characteristics of Scn8a-mutant mice.

Cerebellum (London, England) - 1 Sept 2009

Chen Kejian, Godfrey Donald A, Ilyas Omer, Xu Jiansong, Preston Todd W

Abstract excerpt

Among ten sodium channel alpha-subunit genes mapped in human and mouse genomes, the SCN8A gene is primarily expressed in neurons and glia. Mice with two types of Scn8a null mutations--Scn8a ( med ) and Scn8a ( medTg )--live for only 21-24 days, but those with incomplete mutations-Scn8a ( medJ ) and Scn8a ( medJo )--and those with knockout of Scn8a only in cerebellar Purkinje cells live to adult age. We review...

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Identifiers

PMID: 19424768
DOI: 10.1007/s12311-009-0110-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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