Article
4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms.
PloS one - 23 Mar 2010
Nakamura Kyle J, Gach Johannes S, Jones Laura, Semrau Katherine, Walter Jan, Bibollet-Ruche Frederic, Decker Julie M, Heath Laura, Decker William D, Sinkala Moses, Kankasa Chipepo, Thea Donald, Mullins James, Kuhn Louise, Zwick Michael B, Aldrovandi Grace M
Abstract excerpt
Human antibody 4E10 targets the highly conserved membrane-proximal external region (MPER) of the HIV-1 transmembrane glycoprotein, gp41, and has extraordinarily broad neutralizing activity. It is considered by many to be a prototype for vaccine development. In this study, we describe four subjects infected with viruses carrying rare MPER polymorphisms associated with resistance to 4E10 neutralization. In one case...
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