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Article

Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity.

Journal of virology - 1 Jan 2010

Xu Hengyu, Song Likai, Kim Mikyung, Holmes Margaret A, Kraft Zane, Sellhorn George, Reinherz Ellis L, Stamatatos Leonidas, Strong Roland K

Abstract excerpt

Human 4E10 is one of the broadest-specificity, HIV-1-neutralizing monoclonal antibodies known, recognizing a membrane-proximal linear epitope on gp41. The lipid cross-reactivity of 4E10 has been alternately suggested either to contribute to the apparent rarity of 4E10-like antibody responses in HIV infections, through elimination by B-cell tolerance mechanisms to self-antigens, or to contribute to neutralization...

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Source

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Identifiers

PMID: 19906921
DOI: 10.1128/JVI.02113-09
PMCID: PMC2798360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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