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Article

Randomized double-blind placebo-controlled crossover study to determine the effects of esomeprazole on inhibition of platelet function by clopidogrel.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2011

Fernando H, Bassler N, Habersberger J, Sheffield L J, Sharma R, Dart A M, Peter K H, Shaw J A

Abstract excerpt

BACKGROUND: Pharmacokinetic studies suggest that clopidogrel and esomeprazole are metabolized by similar hepatic enzymes; however, previous studies have not identified a biochemical interaction. OBJECTIVES: To determine whether addition of esomeprazole to patients receiving aspirin and clopidogrel reduces the antiplatelet effects of clopidogrel. PATIENT/METHODS: Patients with a history of an acute coronary...

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Identifiers

PMID: 21696537
DOI: 10.1111/j.1538-7836.2011.04414.x

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VASP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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