Article
Dosimetry Modeling of Inhaled Formaldehyde: Comparisons of Local Flux Predictions in the Rat, Monkey, and Human Nasal Passages
1 Nov 2001
Abstract excerpt
Formaldehyde-induced nasal squamous cell carcinomas in rats and squamous metaplasia in rats and rhesus monkeys occur in specific regions of the nose with species-specific distribution patterns. Experimental approaches addressing local differences in formaldehyde uptake patterns and dose are limited by the resolution of dissection techniques used to obtain tissue samples and the rapid metabolism of absorbed...
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