Article
Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Jun 2010
Kastelijn Elisabeth A, van Moorsel Coline H M, Rijkers Ger T, Ruven Henk J T, Karthaus Vincent, Kwakkel-van Erp Johanna M, van de Graaf E A, Zanen Pieter, van Kessel Diana A, Grutters Jan C, van den Bosch Jules M M
Abstract excerpt
BACKGROUND: Activation of the immune system is suggested to prevent transplant tolerance and to promote the development of bronchiolitis obliterans syndrome (BOS). The innate immune system is activated by the interaction of pathogen-associated molecular patterns of microorganisms with Toll-like receptors (TLRs). Activation of innate immunity via TLRs was shown to be a barrier to the induction of transplantation...
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