Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

doi:10.1073/pnas.88.10.4186

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Article

Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1991

Brunetto M R, Giarin M M, Oliveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, Saracco G, Verme G, Will H

Abstract excerpt

Using an oligonucleotide hybridization assay, we studied the clinical implication of wild-type hepatitis B virus (HBV) and a HBV mutant that is unable to secrete hepatitis B e antigen (HBeAg) because of a translational defect due to a stop codon in the pre-C region in 106 hepatitis B surface antigen-positive patients with chronic hepatitis B. Wild-type HBV was detected in 31 of 42 (73.8%) HBeAg-positive patients,...

Topics

Adolescent
Adult
Aged
Base Sequence
DNA, Viral
Female
Hepatitis B
Hepatitis B Antibodies
Hepatitis B e Antigens
Hepatitis B virus
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immune Tolerance

Male

Middle Aged

Molecular Sequence Data

Mutation

Nucleic Acid Hybridization

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 2034663
DOI: 10.1073/pnas.88.10.4186
PMCID: PMC51623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2034663-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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