Article
Hepatitis B--molecular variants with clinical significance?
The American journal of the medical sciences - 1 Dec 1991
Cuthbert J A
Abstract excerpt
Mutations in the DNA of the hepatitis B virus have been discovered and they may have clinical significance. A single nucleotide substitution resulting in a premature stop codon in the pre-core region of the hepatitis B genome is the most common change. The premature stop codon prevents the synthesis of hepatitis B e antigen (HBeAg), a virally encoded protein normally secreted by hepatocytes. The mutant hepatitis...
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