Article
Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways.
Molecular psychiatry - 1 Jul 2010
Ditzen C, Varadarajulu J, Czibere L, Gonik M, Targosz B S, Hambsch B, Bettecken T, Kessler M S, Frank E, Bunck M, Teplytska L, Erhardt A, Holsboer F, Müller-Myhsok B, Landgraf R, Turck C W
Abstract excerpt
In our biomarker identification efforts, we have reported earlier on a protein that differs in its electrophoretic mobility between mouse lines bred either for high or low trait anxiety. The altered electrophoretic behavior of enolase phosphatase (EP) is now identified to be caused by two single-nucleotide polymorphisms. In both cases, the genetic polymorphism introduces an amino acid change in the protein's...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.