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Cellular and Viral Control over the Initial Events of Human Cytomegalovirus Experimental Latency in CD34+Cells

25 Mar 2010

Abstract excerpt

Human cytomegalovirus (HCMV) persists for the life of its host by establishing a latent infection. The identification of viral and cellular determinants of latency is the first step toward developing antiviral treatments that target and might clear or control the reservoir of latent virus. HCMV latency is established in CD34(+) cells when expression of viral immediate early (IE) proteins that initiate lytic...

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PMID: 20335255
DOI: 10.1128/jvi.00348-10

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