Article
A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Human molecular genetics - 15 Jun 2010
Kalsi Gursharan, Kuo Po-Hsiu, Aliev Fazil, Alexander Jeffry, McMichael Omari, Patterson Diana G, Walsh Dermot, Zhao Zhongming, Schuckit Marc, Nurnberger John, Edenberg Howard, Kramer John, Hesselbrock Victor, Tischfield Jay A, Vladimirov Vladimir, Prescott Carol A, Dick Danielle M, Kendler Kenneth S, Riley Brien P
Abstract excerpt
Studies of alcohol dependence (AD) have consistently found evidence of linkage on chromosome 4q21-q32. A genome-wide linkage scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample also provided its strongest evidence of linkage on chromosome 4q22-q32 using an index of AD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.