Article
Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4.
Molecular psychiatry - 1 Jun 2006
Prescott C A, Sullivan P F, Kuo P-H, Webb B T, Vittum J, Patterson D G, Thiselton D L, Myers J M, Devitt M, Halberstadt L J, Robinson V P, Neale M C, van den Oord E J, Walsh D, Riley B P, Kendler K S
Abstract excerpt
Alcoholism is a relatively common, chronic, disabling and often treatment-resistant disorder. Evidence from twin and adoption studies indicates a substantial genetic influence, with heritability estimates of 50-60%. We conducted a genome scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). Most probands were ascertained through alcoholism treatment settings and were severely affected....
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