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Article

Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.

Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010

Gaballa Ahmed, Newton Gerald L, Antelmann Haike, Parsonage Derek, Upton Heather, Rawat Mamta, Claiborne Al, Fahey Robert C, Helmann John D

Abstract excerpt

Bacillithiol (BSH), the alpha-anomeric glycoside of L-cysteinyl-D-glucosamine with L-malic acid, is a major low-molecular-weight thiol in Bacillus subtilis and related bacteria. Here, we identify genes required for BSH biosynthesis and provide evidence that the synthetic pathway has similarities to that established for the related thiol (mycothiol) in the Actinobacteria. Consistent with a key role for BSH in...

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PMID: 20308541
DOI: 10.1073/pnas.1000928107
PMCID: PMC2851989

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