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Article

Role of Bacillus subtilis BacB in the synthesis of bacilysin.

The Journal of biological chemistry - 13 Nov 2009

Rajavel Malligarjunan, Mitra Ashima, Gopal Balasubramanian

Abstract excerpt

Bacilysin is a non-ribosomally synthesized dipeptide antibiotic that is active against a wide range of bacteria and some fungi. Synthesis of bacilysin (l-alanine-[2,3-epoxycyclohexano-4]-l-alanine) is achieved by proteins in the bac operon, also referred to as the bacABCDE (ywfBCDEF) gene cluster in B. subtilis. Extensive genetic analysis from several strains of B. subtilis suggests that the bacABC gene cluster...

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Identifiers

PMID: 19776011
DOI: 10.1074/jbc.M109.014522
PMCID: PMC2797259

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