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Article

Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds

28 Sept 2020

Abstract excerpt

Scars are a serious health concern for burn victims and individuals with skin conditions associated with wound healing. Here, we identify regenerative factors in neonatal murine skin that transforms adult skin to regenerate instead of only repairing wounds with a scar, without perturbing development and homeostasis. Using scRNA-seq to probe unsorted cells from regenerating, scarring, homeostatic, and developing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32990218
DOI: 10.7554/elife.60066

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