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Article

Role of FGFR2-signaling in the pathogenesis of acne

1 May 2009

Abstract excerpt

It is the purpose of this review to extend our understanding of the fibroblast growth factor (FGF) receptor-2b-signaling network in the pathogenesis of acne. A new concept of the role of FGFR2b-signaling in dermal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comedogenesis, sebaceous gland proliferation and lipogenesis is presented. The FGFR2-gain-of-function mutations...

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Identifiers

PMID: 20436882
DOI: 10.4161/derm.1.3.8474

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