Article
An alternative cyclin-D1 splice site is not linked to inflammatory bowel disease-associated neoplasia.
The International journal of biological markers - 1 Jan 2000
Kanaan Ziad, Eichenberger M Robert, Young Michael, Colliver Daniel, Crawford Nigel, Cobbs Gary A, Hein David W, Galandiuk Susan
Abstract excerpt
BACKGROUND: Inflammatory bowel diseases (IBD) encompass inflammatory disorders affecting the gastrointestinal tract, primarily ulcerative colitis (UC) and Crohn's disease (CD). The risk of developing colorectal cancer (CRC) is increased in patients with IBD. The CCND1 protein is the regulatory subunit of an enzyme that inactivates the retinoblastoma protein, a tumor suppressor protein, and promotes progression...
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