Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians.

doi:10.1038/gene.2010.15

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Article

Evidence that glioma-associated oncogene homolog 1 is not a universal risk gene for inflammatory bowel disease in Caucasians.

Genes and immunity - 1 Sept 2010

Bentley R W, Cleynen I, Gearry R B, Barclay M L, Rutgeerts P, Merriman T R, Ferrante M, Roberts R L, Vermeire S

Abstract excerpt

The transcription factor glioma-associated oncogene homolog 1 (GLI1) has a central function in gastrointestinal tract development and homeostasis. A non-synonymous single-nucleotide polymorphism (SNP) (rs2228226; Q1100E) in GLI1, which impairs GLI1 function in vitro, has been proposed as a risk factor for inflammatory bowel disease (IBD). In this study, we assessed the cumulative evidence for association of GLI1...

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PMID: 20445566
DOI: 10.1038/gene.2010.15

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GLI1

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