Article
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21.
Science (New York, N.Y.) - 23 Nov 2001
Patil N, Berno A J, Hinds D A, Barrett W A, Doshi J M, Hacker C R, Kautzer C R, Lee D H, Marjoribanks C, McDonough D P, Nguyen B T, Norris M C, Sheehan J B, Shen N, Stern D, Stokowski R P, Thomas D J, Trulson M O, Vyas K R, Frazer K A, Fodor S P, Cox D R
Abstract excerpt
Global patterns of human DNA sequence variation (haplotypes) defined by common single nucleotide polymorphisms (SNPs) have important implications for identifying disease associations and human traits. We have used high-density oligonucleotide arrays, in combination with somatic cell genetics, to identify a large fraction of all common human chromosome 21 SNPs and to directly observe the haplotype structure...
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