Article
The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin.
The American journal of pathology - 1 May 2010
Block Karen, Gorin Yves, New David D, Eid Assaad, Chelmicki Tomasz, Reed Amanda, Choudhury Goutam Ghosh, Parekh Dipen J, Abboud Hanna E
Abstract excerpt
Mutations in the von Hippel-Lindau (VHL) gene give rise to renal cell carcinoma. Reactive oxygen species, generated by Nox oxidases, are involved in tumorigenesis. We have previously demonstrated that in VHL-deficient cells, p22(phox)-dependent Nox1 and Nox4 oxidases maintain hypoxia inducible factor-2alpha (HIF-2alpha) protein expression through an Akt-dependent translational pathway. Phosphorylation of tuberin,...
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