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Mechanism of Oxidative DNA Damage in Diabetes

3 Jul 2008

Abstract excerpt

OBJECTIVE: To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells. RESEARCH DESIGN AND METHODS: Phosphorylation of Akt and tuberin, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) levels, and 8-oxoG-DNA glycosylase (OGG1) expression were measured in kidney cortical...

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PMID: 18599524
DOI: 10.2337/db07-1579

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