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Article

Tuberin regulates the DNA repair enzyme OGG1.

American journal of physiology. Renal physiology - 1 Jan 2008

Habib Samy L, Riley Daniel J, Mahimainathan Lenin, Bhandari Basant, Choudhury Goutam Ghosh, Abboud Hanna E

Abstract excerpt

The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. The TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. We investigated a potential role for tuberin in regulating a key DNA repair pathway. Downregulation of tuberin in human renal epithelial cells using siRNA resulted in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17989114
DOI: 10.1152/ajprenal.00370.2007

Genes

OGG1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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