Serial Transcriptome Analysis and Cross-Species Integration Identifies <i>Centromere-Associated Protein E</i> as a Novel Neuroblastoma Target

Abstract excerpt

Cancer genomic studies that rely on analysis of biopsies from primary tumors may not fully identify the molecular events associated with tumor progression. We hypothesized that characterizing the transcriptome during tumor progression in the TH-MYCN transgenic model would identify oncogenic drivers that would be targetable therapeutically. We quantified expression of 32,381 murine genes in nine hyperplastic...

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