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Article

Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival

1 Sept 2022

Abstract excerpt

Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. We previously showed that elevated TS exhibits properties of an oncogene and promotes pancreatic neuroendocrine tumors (PanNETs) with a long latency. To study the causal impact of elevated TS levels in PanNETs, we generated a mouse model with elevated human TS...

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PMID: 36048542
DOI: 10.1172/jci.insight.147417

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