Article

Incoherent collective cell chemotaxis underlies organ dysmorphia in a model of branchio-oto-renal syndrome

2021-01-27

Abstract excerpt

Mutations in the transcriptional co-activator Eya1 cause branchio-oto-renal syndrome (BOR) in humans and the equivalent condition in vertebrates. BOR is characterized by congenital branchial fistulas, malformations of the inner ear and kidney hypoplasia. Here we use the mechanosensory lateral line in zebrafish to better understand the role of Eya1 in organogenesis. The lateral line develops from a primordium forme...

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Literature Corpus work: 69b4a6d6-3325-5a3b-9652-efc95e79916b
DOI: 10.1101/2021.01.27.428404

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