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Article

Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity.

Cellular & molecular immunology - 1 May 2010

Li Weizhong, Wang Gefei, Zhang Heng, Xin Gang, Zhang Dangui, Zeng Jun, Chen Xiaoxuan, Xu Yanxuan, Cui Youhong, Li Kangsheng

Abstract excerpt

Non-structural protein 1 (NS1) is an important virulence factor of the highly pathogenic H5N1 avian influenza virus. A five-amino-acid (5 aa) deletion at position 80-84 and an aspartic acid to glutamic acid substitution at position 92 (D92E) are two major NS1 mutations that are highly correlated with enhanced virulence. To investigate the effect of these mutations in H5N1 virulence, three H5N1-NS1 variants were...

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Identifiers

PMID: 20228833
DOI: 10.1038/cmi.2010.6
PMCID: PMC4002919

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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