Article
Variation in the HLA-G promoter region influences miscarriage rates.
American journal of human genetics - 1 Jun 2003
Ober Carole, Aldrich Carrie L, Chervoneva Inna, Billstrand Christine, Rahimov Fedik, Gray Heather L, Hyslop Terry
Abstract excerpt
The HLA-G gene is primarily expressed in placental cells that invade the maternal decidua during pregnancy. This gene encodes multiple isoforms that fulfill a variety of functions at the maternal-fetal interface throughout gestation. Recently, a null allele for the most abundant HLA-G isoform was associated with recurrent miscarriage in two independent studies, suggesting that reduced levels of the HLA-G1 protein...
Topics
- Abortion, Spontaneous
- Alleles
- Female
- Gene Frequency
- Genetic Variation
- Genotype
- HLA Antigens
- HLA-G Antigens
- Haplotypes
- Histocompatibility Antigens Class I
- Humans
- Mutation
- Polymorphism, Single Nucleotide
- Pregnancy