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Article

Molecular discrimination of type-I over type-II methionyl aminopeptidases.

Biochemistry - 13 Sept 2005

Swierczek Krzysztof, Copik Alicja J, Swierczek Sabina I, Holz Richard C

Abstract excerpt

Two residues that are conserved in type-I methionyl aminopeptidases (MetAPs) but are absent in all type-II MetAPs are the cysteine residues (Escherichia coli MetAP-I: C59 and C70) that reside at the back of the substrate recognition pocket. These Cys residues are 4.4 A apart and do not form a disulfide bond. Since bacteria and fungi contain only type-I MetAPs while all human cells contain both type-I and type-II...

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PMID: 16142902
DOI: 10.1021/bi047752g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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