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Article

CPP-Ala-Ala-Tyr-PABA inhibitor analogs with improved selectivity for neurolysin or thimet oligopeptidase.

Biochemical and biophysical research communications - 5 Feb 2020

Dalio Fernanda M, Machado Maurício F M, Marcondes Marcelo F, Juliano Maria A, Chagas Jair R, Cunha Rodrigo L O R, Oliveira Vitor

Abstract excerpt

Thimet oligopeptidase (TOP, EC 3.4.24.15) and neurolysin (NEL, EC 3.4.24.16) are closely related zinc-dependent metalo-oligopeptidases, which take part in the metabolism of oligopeptides (from 5 to 17 amino acid residues) inside and outside cells. Both peptidases are ubiquitously distributed in tissues. TOP is one of the main intracellular peptide-processing enzymes being important for the antigen selection in...

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PMID: 31761323
DOI: 10.1016/j.bbrc.2019.11.097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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