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Genetic polymorphisms of DNA repair genes and chromosomal damage in workers exposed to 1,3-butadiene.

Carcinogenesis - 1 May 2010

Wang Qi, Wang Ai-hong, Tan Hong-shan, Feng Nan-nan, Ye Yun-jie, Feng Xiao-qing, Liu Geoffrey, Zheng Yu-xin, Xia Zhao-lin

Abstract excerpt

The base excision repair (BER) pathway is important in repairing DNA damage incurred from occupational exposure to 1,3-butadiene (BD). This study examines the relationship between inherited polymorphisms of the BER pathway (x-ray repair cross-complementing group 1 (XRCC1) Arg194Trp, Arg280His, Arg399Gln, T-77C, ADPRT Val762Ala, MGMT Leu84Phe and APE1 Asp148Glu) and chromosomal damage in BD-exposed workers, using...

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Identifiers

PMID: 20223788
DOI: 10.1093/carcin/bgq049

Genes

XRCC1
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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